Predicting Working Memory Capacity Based on Glutamatergic Concentration and its Modulation of Functional Connectivity

Working memory (WM) capacity, the amount of information one can hold online in mind, has a central role cognition. Previous electrophysiological and imaging studies revealed pivotal persistent activity within parietal frontal regions as neural foundations underpinning WM capacity. The best candidate molecules determining are brain’s major excitatory inhibitory neurotransmitters, glutamate gamma-aminobutyric acid (GABA), respectively. However, our knowledge these neurophysiological determinants forming capacity is still poor. Using magnetic resonance spectroscopy (MRS), we examined contribution GABA left intraparietal sulcus (IPS) inferior/middle gyrus (FG) tracking A positive association was found between IPS By utilising resting-state functional MRI, identified negative parieto-cingulate connectivity Individual variation explained by glutamatergic concentration IPS. Moreover, that mediated relationship interparietal This set findings reveals novel mechanistic insight which shapes via connectivity.